Extensive research has been carried out on it as a macromolecular carrier for protein or drug delivery for the application of biomedical medicine. Informed by its architecture, the hydroxyl groups attached to the dextran main chain allow it to undergo oxidation with periodate to yield an input composed of multiple aldehyde groups, which serves as a polymer cross-linker for polymers carrying free amino groups to form the hydrogels . SO,. Gelatin hydrogel is characterized by rapid solubilization in aqueous environment and melts easily in the body temperature range, thus limiting its potential in the biomedical field.