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Essay / Source: “Randomized Control Trial Design” Kenneth Stanley. http://circ.ahajournals.org/content/115/9/1164. Introduction: This article review reviews the article “Design of Randomized Controlled Trials” by Kenneth Stanley which was published in Circulation, Journal of American Heart Association. First, this review will summarize the article. Secondly, it will briefly analyze the structure, content and validity of the article, then it will examine how the information provided is formed and whether the reader can access it comfortably. Next, the journal will critique the article, assessing its authority, timeliness, accuracy, objectivity, and coverage. The journal will also analyze the graphs and tables before ultimately judging the article's accessibility and credibility. The article was very well written and sounds conclusive. Literature Review: The main objective of the article is to check the different models of randomized clinical trials that are considered the gold standard in clinical trials and their effective implementation in clinical studies. clearly mentioned the uniqueness of randomized clinical trials and its association with phase 3 clinical trials. This article discusses balance which is one of the ethical concepts in the design and conduct of clinical trials. It highlighted the limits and practical problems of balance somewhere. He also looked at the different classifications and designs involved in phase 3 clinical trials. He deeply emphasized on the biases involved during randomization and showed the solution to mitigate these issues. article, even basic researchers could understand the importance of randomized clinical trials and...... middle of article ......lved in randomized clinical trials. Meanwhile, this article has highlighted some points about the statistical power and importance of the null hypothesis in brief. Conclusion: This review summarized and critically examined the article “Design of Randomized Controlled Trials” by Kenneth Stanley. The content, structure, strengths and limitations of the article were analyzed and critiqued. The article not only mentions the importance of essential design, randomization and statistical power. He also emphasized the importance of rapid patient recruitment in randomized clinical trials. Overall, this article revealed every part of randomized clinical trials, including study design, randomization, recruitment, and quality. As the research world is always looking for a bias-free environment in research studies. , this article is informative and innovative to follow.
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