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  • Essay / Hypertension Essay - 943

    Hypertension, a complex multifactorial and polygenic disorder, is a major silent disease affecting young people due to their hereditary and modern lifestyle and is a major modifiable cardiovascular risk factor. 1 A positive parental history represents a major risk factor for future hypertension in normotensive offspring.2 Several studies have been conducted in hypertensive offspring to uncover the role of genetic and environmental factors in the pathogenesis of essential hypertension. Cultural, social, and physical environments and high dietary salt intake could further increase the tendency toward hypertension.3 The autonomic nervous system plays a crucial role in the pathogenesis of essential hypertension. Many children of hypertensive parents exhibit early changes in autonomic functions.4 Autonomic abnormalities in the form of increased sympathetic tone and early attenuated parasympathetic activity have been demonstrated in normotensive youth with a parental history of hypertensive hypertension.5 Another risk factor, obesity, is a rapidly growing risk factor. threat to the healthy population and is increasing in our society due to socio-economic changes leading to a sedentary lifestyle and poor dietary habits.6 Weight gain in adolescence and young adults is one of the potential risk factors for the further development of hypertension. A study of young obese Indian adults demonstrates autonomic dysregulation in obese subjects.7 A short-term heart rate variability (HRV) index provides a non-invasive, quantitative method to study autonomic effects on the heart.8 Although While it is clear that parental history has a global impact on the hypertension risk profile of offspring, little work has been done...... middle of article ......ics , we resort to a manual calculation of the successive RR intervals. This series of RR intervals is subjected to analyzes in the time domain and in the frequency domain. In the time domain analysis, SDNN (standard deviation of all normal sinus RR intervals), an index of overall heart rate variability, RMSSD (root mean square of successive normal sinus RR intervals), and the percentage of differences between Adjacent normal RR intervals exceeding 50 milliseconds (pNN50%) are studied. RMSSD and pNN50 show a greater correlation with parasympathetic nervous activity. In frequency domain analysis, spectral estimates of RR intervals are made by integrating power as total power (TP) from 0.04 to 0.40 Hz, low frequency (LF) power from 0.04 to 0.15 Hz, HF (high frequency) power from 0.15 to 0.40. Hz. The power contained in the VLF band is not calculated due to its doubtful physiological significance..