Table of ContentsWhat is WAGR syndrome?Which gene is responsible for the disorderAre there currently treatments for these disordersWhat is WAGR syndrome?WAGR syndrome is a disease rare that can affect both sexes. It is more common for babies to be born with the syndrome rather than to be diagnosed with the condition later in life. Babies born with WAGR are at high risk of being diagnosed with cancer, may develop eye problems, as well as delay in mental progression. WAGR is the abbreviation for four different types of diseases found in children: Wilms tumor, aniridia, genitourinary problems and mental retardation. Say no to plagiarism. Get a tailor-made essay on “Why violent video games should not be banned”?Get the original essayWhich gene is responsible for the disorderIs there a mutation that causes this disorder? WAGR syndrome is caused by mutations in a group of genes located on chromosome 11 that are removed from the chromosome. The deleted genetic material often contains genes needed for the baby's development, meaning there is now only one copy of the genes, not two. This type of genetic change often occurs during an infant's early stages of development. What are the signs and symptoms of this disorder? Symptoms of WAGR syndrome often appear after the birth of a baby. For example, baby's kidney enlargement can be discovered through a prenatal ultrasound, eye problems are detected during the neonatal period, as are genital complications. Babies born with WAGR syndrome may develop more problems as they grow, increasing the risk of failure of their kidneys, eyes, ovaries (for women), and testicles (for boys). ). Half of people who are diagnosed with WAGR have kidney cancer syndrome (also known as Wilms tumor). Symptoms include blood in the urine, loss of appetite, weight loss, low-grade fever, loss of energy, and/or inflammation of the abdomen. What usually happens with aniridia is that the irises in the baby's eyes don't grow, leaving them without colored irises. This condition is more common in babies with WAGR syndrome. Symptoms that may occur as the baby grows include eye cataracts, rapid eye movements, and vision loss. Genital and urinary (genitourinary) problems can sometimes occur when WAGR syndrome is diagnosed. If a man has these problems, the symptoms that appear may be problems with the testicles or a lack of growth in this part of the body. In women, symptoms often include malfunctioning ovaries and abnormal growth of the uterus and vagina. Sometimes problems with the genitals can cause a newborn's gender to be unclear. Mental retardation and delayed child development are common in WAGR syndrome. Each person's mental retardation is different. The severity of mental retardation can range from severe to mild. However, some children with WAGR syndrome may still have normal mental development. Other symptoms that may occur with WAGR syndrome are: Developmental, behavioral and/or psychiatric disorders such as autism, attention deficit disorder, obsessive compulsive disorder, anxiety and depressionObesity and cholesterol levels highChronic kidney failure (usually occurs after age 12)Asthma and pneumoniaEpilepsyPancreatitisWhat are the patterns of inheritance (how is it passed from one generation to the next), e.g..