Brain and mental illnesses: major depressive disorder It is difficult to live with a disorder called major depression (MDD) if individuals do not find positive ways to manage their depression, such as receive professional assistance or simply motivate yourself, for example by listening to music to motivate yourself. In this article, presenting the case study of Jayden Wyler (anonymous, personal communication, April 6, 2014), the causes and how he copes with his symptoms of major depressive disorder, among other biological aspects. DefinitionAccording to Alleydog.com (2014), Major depressive disorder classified as a mood disorder in which people experience periods of hopelessness and sadness that last more than 2 weeks and do not appear to have a specific cause (although one it varies). It is more than just "having the blues", but it is a period of intense psychological pain that includes despair, feelings of worthlessness, loss of pleasure in things that were previously enjoyable, etc. (para. 1)Case StudyJayden Wyler (anonymous, personal communication, April 6, 2014) lives with his three siblings, an uncle, and his mother in a four-bedroom house. He shared the room with his older brother. Father's involvement has been non-existent since the age of 4. His mother worked nights and his uncle worked days when they were at school. Jayden's mother never failed to always give him hugs and kisses and tell him she loved him. Jayden (anonymous, personal communication, April 6, 2014) states: “My mom always asked me how your day was and if you needed help with anything, but I always said I'm fine and everything is fine. GOOD. » Jayden's mother wanted to be there for him, but he never expressed his feelings or problems to her... middle of paper ...... Daskalakis, ZJ (2011). Evidence for GABAergic inhibitory deficits in major depressive disorder. Neuroscience and Biobehavioral Reviews, 35(3), 818-825. doi:10.1016/j.neubiorev.2010.10.002 Fritscher, L. (2013). Sertraline: Understanding how zoloft works. Retrieved from http://phobias.about.com/od/phobiaslist/a/Sertraline.htm Luscher, BB, Shen, QQ, and Sahir, NN (2011). The GABAergic deficit hypothesis of major depressive disorder. Molecular Psychiatry, 16(4), 383-406. doi:10.1038/mp.2010.120Wagner, K.D., Ambrosini, P., Rynn, M., Wohlberg, C., Yang, R., Greenbaum, M., Childress, A., & Donnelly, C. (2003 ). Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder: two randomized controlled trials. JAMA. 290(8), 1033-41. doi:10.1001/jama.290.8.1033. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12941675