In this study, Atenolol-Atorvastatin (AA) oral disintegrating tablets (MDT) were formulated for hypertensive patients who experience difficulty in swallowing solid dosage forms, especially tablets and capsules, due to sore throat, vomiting, non-compliance and inconvenience. Superdisintegrants are the main players in this dosage form to impart rapid disintegration. Fifteen PCT formulations were prepared based on the different concentrations of two superdisintegrants (Crosscarmellose sodium and Kyron-T134). Three different techniques, namely direct compression, effervescent and sublimation methods, were used to find out the effect of manufacturing processes, nature and concentration of superdisintegrants on various characteristics of MDTs. Five formulations were prepared by each method. Pre-compression studies such as bulk density, tapped density, angle of repose, Carr compressibility index, Hausner ratio and compatibility studies such as Fourier transform infrared spectroscopy (FTIR ) and differential scanning calorimetry (DSC) were performed. Various characteristics such as hardness, thickness, diameter, weight variation, friability, disintegration time, wetting time of dissolution studies, wetting volume, water absorption rate, the modified disintegration, content uniformity and stability of the formulated MDTs were evaluated. Finally, the results were statistically analyzed by applying a one-way ANOVA test. It was observed that formulation F13 containing Kyron-T134 (6%) and Crosscaramellose sodium (2%) was the best among the fifteen formulations in all aspects like disintegration time, wetting volume, time mooring, release studies, etc. This sublimation method is the best among three methods because F13 was prepared in middle of paper......it includes direct compression, sublimation method, effervescent method, etc. Each method has its own advantages and disadvantages, but most often direct compression is used in the preparation of orodispersible tablets [8-10]. In the present study, PCTs of atenolol and atorvastatin were formulated using different techniques and superdisintegrants to reduce dose frequency and improve patient compliance toward treatment. Atenolol belongs to the class of β-blockers and is currently used in the treatment of hypertension. It is also used in the combined treatment of hypertension [11]. Atorvastatin is an antihyperlipidemic drug used to reduce blood cholesterol levels. This medicine belongs to the statins and works by inhibiting the enzyme 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase which is present in the liver and plays an important role in the production of cholesterol. [12].